Abuse Resistant Drug Formulation

摘要

A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat/wax and have improved controlled release and/or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.

主权项

1. A pharmaceutical composition, comprising:
a solid extended release formulation comprising:
an opioid or a salt thereof;a first material that is substantially water insoluble and at least partially alcohol soluble; anda second material that is hydroxypropylmethylcellulose; wherein the first material and second material together are provided in an amount from about 0.1 to about 90 percent by weight of the formulation.