发明名称 |
TEST FOR HEMOLYTIC POTENTIAL OF PHARMACEUTICAL PRODUCTS AND FORMULATIONS FOR RISK MINIMIZATION |
摘要 |
A non-hemolytic acidic composition comprising an immunoglobulin selected from immunoglobulin A, immunoglobulin G or immunoglobulin M at a pH value in the range of 4.65 to 5.7 comprising one or more excipients selected from amino acids, sugars and sugar alcohols in a concentration range of 100-350 mmol/l, in particular 200-350 mmol/l, characterized in that it displays an optical density (OD) in the range of 0.14 to −0.1 when the OD is determined in a spectrophotometer at 414 nm at a film thickness of 0.825 mm; and its use in an assay for determination of the hemolytic potential of intravenously applied pharmaceuticals and compositions and preparations displaying a reduced potential of hemolysis when being applied intravenously. |
申请公布号 |
US2015250879(A1) |
申请公布日期 |
2015.09.10 |
申请号 |
US201314431498 |
申请日期 |
2013.09.26 |
申请人 |
OCTAPHARMA AG |
发明人 |
Heger Andrea;Svae Tor-Einar;Roemisch Juergen;Zoechling Alfred |
分类号 |
A61K47/18;C07K16/18;G01N33/49 |
主分类号 |
A61K47/18 |
代理机构 |
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代理人 |
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主权项 |
1. A non-hemolytic acidic composition comprising an immunoglobulin selected from immunoglobulin A, immunoglobulin G or immunoglobulin M at a pH value in the range of 4.65 to 5.7 comprising one or more excipients selected from amino acids, sugars and sugar alcohols in a concentration range of 100-350 mmol/l, characterized in that it displays an optical density (OD) in the range of 0.14 to −0.1 when the OD is determined in a spectrophotometer at 414 nm at a film thickness of 0.825 mm. |
地址 |
Lachen CH |