| 发明名称 |
Oncolytic Measles Virus |
| 摘要 |
The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein. |
| 申请公布号 |
US2015250838(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514719906 |
申请日期 |
2015.05.22 |
| 申请人 |
LAUER Ulrich M.;BITZER Michael;LAMPE Johanna;ZIMMERMANN Martina;BERCHTOLD Susanne;LANGE Sebastian;NEUBERT Wolfgang J.;BOSSOW Sascha |
发明人 |
LAUER Ulrich M.;BITZER Michael;LAMPE Johanna;ZIMMERMANN Martina;BERCHTOLD Susanne;LANGE Sebastian;NEUBERT Wolfgang J.;BOSSOW Sascha |
| 分类号 |
A61K35/768;C12N9/78;C12N7/00 |
主分类号 |
A61K35/768 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising a recombinant measles virus comprising a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. |
| 地址 |
Tuebingen DE |
