RECOMBINANT PLAZMID DNA pCL2h-1I1G PROVIDING SYNTHESIS OF POLYPEPTIDE WITH PROPERTIES OF LIGHT CHAIN OF HUMAN ANTIBODY AGAINST INTERLEUKIN-18, RECOMBINANT PLAZMID DNA pCH2g-1I1G PROVIDING SYNTHESIS OF POLYPEPTIDE WITH PROPERTIES OF HEAVY CHAIN OF HUMAN ANTIBODY AGAINST INTERLEUKIN-18 AND RECOMBINANT HUMAN ANTIBODY fh1I1G WITH ABILITY TO BIND INTERLEUKIN-18

摘要

FIELD: biotechnologies.SUBSTANCE: recombinant plazmid DNAs pCL2h-1I1G and pCH2g-1I1G providing in eukaryotic cells the synthesis of light and heavy chains of human antibody fh1I1G, capable to bind interleukin-18; and also the antibody obtained from eukaryotic cells, transfected by such recombinant plazmid DNAs, are offered.EFFECT: invention allows to obtain the antibody capable to bind with interleukin-18 and having properties of extracted full-size human antibody of the class IgG1 that can be applicable in therapy.3 cl, 9 dwg, 6 ex