| 发明名称 |
FIBROTIC NON-HUMAN ANIMAL, AND USE THEREOF |
| 摘要 |
The present invention provides a non-human animal IKK² which shows fibrosis of tissue, since it lacks IKK² gene in a myofibroblast- and/or smooth muscle cell-specific manner. Since the non-human animal shows pathology highly similar to scleroderma, it is extremely useful as an animal model of scleroderma. |
| 申请公布号 |
EP2915881(A1) |
申请公布日期 |
2015.09.09 |
| 申请号 |
EP20130851788 |
申请日期 |
2013.10.31 |
| 申请人 |
KYOTO UNIVERSITY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ASHIDA, NOBORU;YOKODE, MASAYUKI;KARIN, MICHAEL;NGUYEN TIEN, DAT |
| 分类号 |
C12N15/09;A01K67/027;A61K49/00;C12N9/12;G01N33/50 |
主分类号 |
C12N15/09 |
| 代理机构 |
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