DOUBLE-STRANDED NUCLEIC ACID MOLECULE, CANCER CELL PROLIFERATION INHIBITOR AND PHARMACEUTICAL AGENT SUITABLE FOR PREVENTION OR TREATMENT OF UTERINE CANCER, BREAST CANCER AND BLADDER CANCER

摘要

The present invention aims to provide a double-stranded nucleic acid molecule (e.g., siRNA) which can effectively inhibit the proliferation of uterine, breast and bladder cancer cells by suppressing the expression of at least one target gene of COX7RP and Efp genes (estrogen-responsive genes); a cancer cell proliferation inhibitor; and a pharmaceutical agent. Specifically, the present invention relates to a double-stranded nucleic acid molecule for suppressing the expression of at least one of COX7RP and Efp genes which includes (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 38 and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in (a); a cancer cell proliferation inhibitor with the double-stranded nucleic acid molecule and against at least one of uterine, breast and bladder cancer cells; and a pharmaceutical agent with the cancer cell proliferation inhibitor and against at least one of uterine, breast and bladder cancers.