| 摘要 |
The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia. |
| 主权项 |
1. A composition comprising a nucleic acid molecule for inhibiting the expression of intracellular adhesion molecule 1 (ICAM-1), which comprises at least one of the nucleotide sequences according to SEQ ID No. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14, wherein the composition is a physiological solution for the incubation of organs, and comprises a buffer substance, salts and if necessary, other auxiliaries, actives, additives or preservatives. |
