Mid-regional pro-atrial natriuretic peptide (pro-ANP) for the identification of patients with atrial fibrillation with an onset of less than 48 hours ago

摘要

The invention relates to a method for the determination of the time from onset of atrial fibrillation to presentation in a patient comprising the steps of: providing a sample of a bodily fluid of said patient, determining the level of proANP (SEQ ID NO: 1) or fragments thereof in said sample, correlating the level of proANP or fragments thereof to the time from the onset of atrial fibrillation to presentation of said patient, wherein said fragments have a length of at least 6 amino acid residues.

主权项

1. A method for the determination of the time from onset of atrial fibrillation to presentation of a patient comprising the steps of:
(i) providing a sample of a bodily fluid of said patient, (ii) determining the level of proANP fragment MR-proANP (SEQ ID No: 4) in said sample, (iii) correlating the level of proANP fragment MR-proANP (SEQ ID No: 4) to the time from the onset of atrial fibrillation to presentation of said patient, and (iv) determining whether the time from the onset of atrial fibrillation to presentation of the patient is at or above a time cut-off value or below said time cut-off value,
wherein said time cut-off value is chosen from 48 hours and 24 hours.