| 发明名称 |
MLK4 gene, a new diagnostic and prognostic marker in cancers |
| 摘要 |
An in vitro diagnostic method for determining invasive potential of cancer comprising measuring MLK4 gene expression in a cancer cell sample, wherein MLK4 gene overexpression is indicative of an invasive cancer, preferably a colorectal, bladder, breast, gastric, melanoma, lung, ovary or GMB cancer. |
| 申请公布号 |
US9127319(B2) |
申请公布日期 |
2015.09.08 |
| 申请号 |
US201013704784 |
申请日期 |
2010.06.15 |
| 申请人 |
|
发明人 |
Bardelli Alberto;Martini Miriam |
| 分类号 |
C12Q1/68;C07K16/40;C12N15/113;G01N33/574 |
主分类号 |
C12Q1/68 |
| 代理机构 |
Nixon & Vanderhye P.C. |
代理人 |
Nixon & Vanderhye P.C. |
| 主权项 |
1. An in vitro diagnostic method for determining the invasive potential of a tumor comprising measuring MLK4 gene expression in a tumor cell sample material of a patient;
measuring at least one activating KRAS gene mutation in said tumor cell sample material; and wherein an increased MLK4 gene expression as compared to normal level of MLK4 gene expression, and the presence of at least one activating KRAS gene mutation, indicates that the tumor is invasive. |
| 地址 |
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