| 发明名称 | Synthetic phytase variants | ||
| 摘要 | The invention relates to a synthetic phytase with elevated thermostability, elevated stability to acids at p H 2, elevated stability to pepsin and with a broadened active p H range, and to an isolated nucleic acid sequence coding for a synthetic phytase and to the use of the phytase in an animal feed for reducing the phosphate content in the slurry and to animal feed additives and animal feeds comprising the synthetic phytase. | ||
| 申请公布号 | US9127260(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201214113100 | 申请日期 | 2012.04.18 |
| 申请人 | BASF SE | 发明人 | Haefner Stefan;Welzel Annegret;Thummer Robert |
| 分类号 | C12N9/16;A23K1/165 | 主分类号 | C12N9/16 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. A phytase comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 24 and at least one modification selected from the group consisting of S1-; D2-,E; T3Q, A4G,E; PSA; A6S,D; G7K; F8Y,M; Q9K; K12R; L16V; N33D,M; H37Y; R67L; Q71E; P75N; K76N,I; D77T; N78T; D92A,E,N,T,V; Q109N,E; Q118S; N119A,T; I120L; Q121T; A123V; S136K; Q141K; A144E; T152G,A; E155N; T156G; Q159N; S164E; A166E,H; Q193L; A200N; S217G; D258N; M260I; S261H; K268N; N270Q; Q276N; I300L; T322Q; D345G; N346G; L371A; H374N; D398E and Q406K based on the amino acid position according to SEQ ID NO: 24. | ||
| 地址 | Ludwigshafen DE | ||