| 摘要 |
The disclosure relates to compounds of formula (I):;
wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates. |
| 主权项 |
1. A compound of general formula (I) below: in which: R1 and R4 are independently selected from the group consisting of H, Me, Et, CO2Rc, CH2ORc, ORc, F, Cl and C(═O)NH(Rd); in which Rc is chosen from H, (C1-C6)alkyl, substituted (C1-C6)alkyl, (C3-C7)cycloalkyl, substituted (C3-C7)cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl; and in which Rd is chosen from H, (C1-C6)alkyl, substituted (C1-C6)alkyl, (C3-C7)cycloalkyl, substituted (C3-C7)cycloalkyl, and optionally substituted (C3-C7)heterocycloalkyl comprising from 1 to 3 heteroatoms chosen from N, O and S; R3 is O(CH2)nN(Me)2 with n=2, 3 or 4, or NH(CH2)2N(Me)2; and R2 is F; R5 is selected from the group consisting of NMe(Et), NH(iPr), N(Et)2, N(iPr)2, NEt(iPr), pyrrolidinyl, piperidinyl, morpholinyl, N-methylpiperazinyl, NH(Cy), N(Cy)2, NMe(iPr), NH(tBu), NH(iBu), N(nBu)2, piperazinyl, NH(Et), N(nPr)2 and NEt(iPr);or a salt thereof. |
