| 摘要 |
The efficacy and safety of laser medical treatments are ensured by performing a combination of measurement techniques to examine tissue properties in order to control characteristics of the laser treatments of cartilaginous tissues. In some aspects, a treatment tool is provided that is capable of taking and providing feedback relating to multiple measurements, including temperature measurements (in particular, radiometry), mechanical measurements, light scattering, speckle interferometry, optoacoustic measurements, and monitoring tissue electrical characteristics. The device is capable of providing feedback during the course of laser treatment of tissue to increase the safety and efficacy of treatment. |
| 主权项 |
1. A device for laser treatment of cartilaginous tissues, the device comprising:
a handheld tool comprising:
a cylinder having a lumen, a proximal end, and a distal end, the cylinder having a longitudinal axis along a length of the cylinder from the proximal end to the distal end;a working optical fiber passing through the lumen of the cylinder and configured to transmit through the lumen a first beam of laser light having properties comprising a wavelength, power, pattern, and pulse profile, wherein the first beam of laser light is configured to produce a working radiation that provides a non-destructive irreversible modification of a cartilaginous tissue;a diagnostic optical fiber passing through the lumen of the cylinder and configured to transmit through the lumen a second beam of laser light having properties comprising a wavelength, power, pattern, and pulse profile, the second beam of laser light configured to produce a diagnostic radiation or to receive diagnostic light from the cartilaginous tissue;a fiber-optic irradiator housed within the cylinder at the distal end and configured to deliver one or both of the working radiation and the diagnostic radiation to the cartilaginous tissue;an optical adapter housed within the cylinder, the optical adapter interfacing the diagnostic optical fiber and the working optical fiber with the fiber-optic irradiator for delivery of the first or second beams of laser light;a locking mechanism of the cylinder, the locking mechanism comprising a first subunit and a second subunit, the first subunit comprising at least one spring positioned in a slot, and the second subunit comprising at least one ball, the ball configured to compress the spring into the slot in a direction parallel to the longitudinal axis of the cylinder, wherein the first and second subunits are structurally configured to securely engage with each other synchronously with the compression;a plurality of sensors on or within the cylinder, wherein each sensor is independently capable of measuring a physical or chemical characteristic of the cartilaginous tissue during application of the working radiation or the diagnostic radiation to the cartilaginous tissue; a feedback control system connected to the plurality of sensors, wherein the feedback control system is configured to analyze a combination of the measurements of the plurality of sensors, and to process the measurements in real time to provide feedback, wherein the measurement processing comprises:
identifying threshold conditions that trigger a modification of treatment conditions, andidentifying modified treatment conditions responsive to a change in a characteristic of the cartilaginous tissue following treatment as measured by the sensors; and a laser control unit configured to control the first and second beams of laser light, wherein the laser control unit is configured to modify one or more properties of the first or second beams of laser light based at least in part on the threshold conditions and modified treatment conditions identified by the feedback control system. |
