发明名称 |
processos de preparo de formas cristalinas a e b de ilaprazol e processo para conversão das formas cristalinas |
摘要 |
<p>Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent) a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.</p> |
申请公布号 |
BR112012012212(A2) |
申请公布日期 |
2015.09.08 |
申请号 |
BR20121112212 |
申请日期 |
2010.12.08 |
申请人 |
IL-YANG PHARM. CO., LTD. |
发明人 |
DONG YEON KIM;HEE YUN KIM;JAE SOO SHIN;JUN YEOUN LEE;JUNG WOO KIM;KWI HYUNG CHO;SANG DON NAM;SUNG TAE PARK |
分类号 |
C07D235/24;C07D401/14;C07D403/14 |
主分类号 |
C07D235/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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