| 发明名称 | Anti-human HER3 antibodies and uses thereof | ||
| 摘要 | The present invention provides for isolated anti-human-HER3 antibodies or fragments thereof. More particularly the present invention provides an isolated monoclonal antibody that specifically binds to the extracellular domain of HER-3 and competes for binding to the extracellular domain of human HER-3 with the antibody produced obtainable from hybridoma deposited as CNCM-I-4486. The antibodies described in the present invention are useful for the treatment of cancer. | ||
| 申请公布号 | US9127065(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201214118747 | 申请日期 | 2012.05.21 |
| 申请人 | Institut National de la Sante et de la Recherche Medicale (INSERM);Centre Val d'Aurelle—Paul Lamarque;Universite de Montpellier 1 | 发明人 | Chardes Thierry;Pelegrin Andre;Larbouret Christel;Gaborit Nadege;Lazrek Yassamine |
| 分类号 | A61K39/395;C07K16/28;C07K16/32 | 主分类号 | A61K39/395 |
| 代理机构 | Whitham Curtis Chistofferson & Cook, PC | 代理人 | Whitham Curtis Chistofferson & Cook, PC |
| 主权项 | 1. An isolated monoclonal antibody that specifically binds to the extracellular domain of HER-3 produced by or obtainable from a hybridoma deposited as CNCM-I-4486 or that competes for binding to the extracellular domain of human HER-3 with the antibody being produced by or obtainable from a hybridoma deposited as CNCM-I-4486. | ||
| 地址 | Paris FR | ||