发明名称 |
Reagent for measuring degree of oxidative stress and method of measuring degree of oxidative stress |
摘要 |
The present invention provides a reagent for measuring a degree of oxidative stress that includes a compound represented by the following general formula (I) or a salt thereof, and a method of measuring a degree of oxidative stress using the reagent for measuring a degree of oxidative stress. In the general formula (I), R1, R2, R3 and R4 each independently represent a hydrogen atom, an ethyl group, an isopropyl group, a hydroxyalkyl group that has 1 to 4 carbon atoms, or a phenyl group, and at least one of R1, R2, R3 or R4 represents an isopropyl group, a hydroxyalkyl group having 1 to 4 carbon atoms, or a phenyl group.; |
申请公布号 |
US9126895(B2) |
申请公布日期 |
2015.09.08 |
申请号 |
US201314138076 |
申请日期 |
2013.12.22 |
申请人 |
ARKRAY, Inc. |
发明人 |
Omiya Kazuhiro;Imai Toshihiro;Ashibe Emi |
分类号 |
G01N33/50;G01N33/48;G01N33/00;C07C215/68;C07C211/55;C07C211/54;G01N33/84 |
主分类号 |
G01N33/50 |
代理机构 |
Morgan, Lewis & Bockius LLP |
代理人 |
Morgan, Lewis & Bockius LLP |
主权项 |
1. A reagent for measuring a degree of oxidative stress, comprising a compound represented by the following general formula (I) or a salt thereof: wherein, in the general formula (I), R1 is a hydrogen atom; R2 is an isopropyl group; R3 is a hydrogen atom, an ethyl group, or a hydroxyalkyl group having 1 to 4 carbon atoms; and R4 is a hydroxyalkyl group having 1 to 4 carbon atoms or a phenyl group; R1 is a hydrogen atom; R2 is a hydrogen atom; R3 is a hydrogen atom; and R4 is a hydroxyalkyl group having 1 to 4 carbon atoms or a phenyl group; R1, R2, R3 and R4 each independently is an ethyl group, an isopropyl group, a hydroxyalkyl group having 1 to 4 carbon atoms, or a phenyl group, where at least one R1, R2, R3 or R4 is an isopropyl group, a hydroxyalkyl group having 1 to 4 carbon atoms, or a phenyl group; or at least one of R1, R2, R3 or R4 is a phenyl group, and at least one of R1, R2, R3 or R4 is a hydroxyalkyl group having 1 to 4 carbon atoms, and a nitrogen atom to which the phenyl group is bonded and a nitrogen atom to which the hydroxyalkyl group having 1 to 4 carbon atoms is bonded are different from each other. |
地址 |
Kyoto JP |