Compounds for use in the treatment of bacterial infection

摘要

This invention relates to a compound of Formula 1A:;
or a pharmaceutically acceptable salt thereof; wherein R1 to R4, R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof; and method of using same for reducing or reversing bacterial resistance to at least one aminoglycoside antibiotic.

主权项

1. A compound of Formula 1A: or a pharmaceutically acceptable salt thereof; wherein R1 is selected from the group consisting of OH R2 is selected from the group consisting of OH and R3 is selected from the group consisting of H, NH2 and OH; R4 is selected from the group consisting of NH2 and R7 is selected from the group consisting of H and CH3; R8 is selected from a group consisting of OH Y isand X is NH,
R6 is selected from the group consisting of OH, CH3, and OCH3; n is an integer from 2 to 5; and R9, R10, R11 and R12 are each independently selected from the group consisting of H and C1-6 alkyl; provided that when the dotted line is a double bond, R3 of the residueis H.