| 发明名称 | Process for preparation of substantially pure fosamprenavir calcium and its intermediates | ||
| 摘要 | The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof. | ||
| 申请公布号 | US9127029(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201414285810 | 申请日期 | 2014.05.23 |
| 申请人 | LUPIN LIMITED | 发明人 | Arora Surinder Kumar;Shabade Samir Shanteshwar;Kumar Gaurav;Ray Purna Chandra;Singh Girij Pal |
| 分类号 | C07D307/20;C07F9/655;C07D405/12;G01N30/16 | 主分类号 | C07D307/20 |
| 代理机构 | Cantor Colburn LLP | 代理人 | Cantor Colburn LLP |
| 主权项 | 1. Fosamprenavir calcium (Ia) substantially free of R-isomer impurity (Ib). | ||
| 地址 | IN | ||