M/Z targeted attenuation on time of flight instruments

摘要

A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyzer are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyzer and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity.

主权项

1. A method of mass spectrometry comprising:
separating ions according to their ion mobility; providing a Time of Flight mass analyser comprising an ion detector; and controlling ions which are onwardly transmitted to said Time of Flight mass analyser by attenuating first ions having: a first physico-chemical property comprising ion mobility within one or more first ranges; and a second physico-chemical property comprising mass or mass to charge ratio within one or more second ranges which would otherwise be transmitted to said Time of Flight mass analyser and which have been determined to have or which are predicted to have, based upon a pre-scan acquisition, a relatively high intensity such as to cause saturation of said ion detector.