Neurturin molecules

摘要

Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease.

主权项

1. A method of treating Parkinson's disease, comprising administering to a patient in need of such treatment a therapeutically effective amount of a polypeptide comprising the amino acid sequence shown in SEQ ID NO:4.