Anti-Notch1 antibodies

摘要

The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.

主权项

1. An antibody that binds to Notch1, wherein the antibody comprises:
(a) a heavy chain CDR1 as set forth in SEQ ID NO: 73, (b) a heavy chain CDR2 as set forth in SEQ ID NO: 77, (e) a heavy chain CDR3 as set forth in SEQ ID NO: 81, (d) a light chain CDR1 as set forth in SEQ ID NO: 99, (e) a light chain CDR2 as set forth in SEQ ID NO: 101, and (f) a light chain CDR3 as set forth in SEQ ID NO: 103.