Extracts from kibdelos porangium as antibacterial agents

摘要

The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.;

主权项

1. A method of inhibiting growth of bacteria, the method comprising treating Clostridium difficile with an effective amour of one or more purified compounds selected from compounds of formula I and formula II: and pharmaceutically acceptable salts thereof,wherein:
R1 and R2 are independently selected from the group consisting of hydrogen and halogen; and R3 selected from the group consisting of hydrogen and C1-C6 alkyl; and and pharmaceutically acceptable salts thereof, wherein: R1 and R2 are independently selected from the group consisting of hydrogen and halogen; and R3 is hydrogen.