| 发明名称 | Annexin 1 antibody | ||
| 摘要 | The present invention provides a specific binding molecule raised against the human Anx-A1 protein having the amino acid sequence shown in FIG. 2A. The present invention also relates to the sue of such a specific binding molecule in the treatment of T cell-mediated disease. | ||
| 申请公布号 | US9127051(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201113702593 | 申请日期 | 2011.06.09 |
| 申请人 | Queen Mary & Westfield College, University of London | 发明人 | D'Acquisto Fulvio;Perretti Mauro |
| 分类号 | C07K16/00;C07K16/46;C07K16/24;C07K16/18;A61K39/395;A61K45/06;A61K39/00 | 主分类号 | C07K16/00 |
| 代理机构 | Pepper Hamilton LLP | 代理人 | Pepper Hamilton LLP |
| 主权项 | 1. An antibody or fragment thereof that binds human Anx-A1 having the amino acid sequence of SEQ ID NO:8, said antibody or fragment thereof comprising Complementarity Determining Regions (CDRs) VLCDR1, VLCDR2, VLCDR3, VHCDR1, VHCDR2 and VHCDR3, each having a respective amino acid sequence as follows in which(SEQ ID NO: 2)VLCDR1 is KASENVVTYVS(SEQ ID NO: 3)VLCDR2 is GASNRYT(SEQ ID NO: 4)VLCDR3 is GQGYSYPYT(SEQ ID NO: 5)VHCDR1 is GYTFTNYWIG(SEQ ID NO: 6)VHCDR2 is DIYPGGDYTNYNEKFKG(SEQ ID NO: 7)VHCDR3 is WGLGYYFDY. | ||
| 地址 | London GB | ||