| 摘要 |
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy,;
wherein
R1 represents heteroaryl, -carbocyclyl-heteroaryl, -alkenylheteroaryl or -alkylheteroaryl;R2 represents alkyl; carbocyclyl which may optionally be substituted by alkyl; alkenyl; alkynyl, provided a triple bond is not adjacent to X; -alkyl-aryl; -alkyl-heteroaryl; -alkyl-heterocyclyl in which heterocyclyl may optionally be substituted by alkyl; -alkyl-carbocyclyl in which carbocyclyl may optionally be substituted by alkyl; aryl; heteroaryl; or H;X represents S or NR3;R3 represents H or C1-4 alkyl. |
| 主权项 |
1. A compound of formula (I),wherein
R1 represents benzimidazole; R2 represents
alkyl;carbocyclyl which may optionally be substituted by alkyl;alkenyl;alkynyl, provided a triple bond is not adjacent to X;-alkyl-aryl which may optionally be substituted by alkyl, alkoxy, or halogen;-alkyl-carbocyclyl in which carbocyclyl may optionally be substituted by alkyl; oraryl which may optionally be substituted by alkyl, alkoxy, or halogen;wherein carbocyclyl is defined as a saturated or partially unsaturated one, two, or three carbon ring system comprising between three and twelve ring carbon atoms; X represents S or NR3; R3 represents H or C1-4 alkyl;or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof;with the proviso that the following compounds are excluded from the scope of formula (I): |
