| 发明名称 | Anti-cancer compositions and methods | ||
| 摘要 | Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation. | ||
| 申请公布号 | US9126911(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201313785778 | 申请日期 | 2013.03.05 |
| 申请人 | The Penn State Research Foundation | 发明人 | Robertson Gavin P.;Sharma Arati K.;Sharma Arun K.;Amin Shantu G.;Desai Dhimant H. |
| 分类号 | A61K31/21;C07C391/00;A61K31/095;A61K45/06;C07C251/00 | 主分类号 | A61K31/21 |
| 代理机构 | Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C. | 代理人 | Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C. |
| 主权项 | 1. A composition comprising an isoselenocyanate having the structural formula: where R′ is a substituted or unsubstituted, branched or straight chain, lower alkyl group, and where n is an integer in the range of 3-8, inclusive. | ||
| 地址 | University Park PA US | ||