发明名称 Conjugated antisense compounds and their use
摘要 Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
申请公布号 US9127276(B2) 申请公布日期 2015.09.08
申请号 US201414267842 申请日期 2014.05.01
申请人 Isis Pharmaceuticals, Inc. 发明人 Prakash Thazha P.;Seth Punit P.;Swayze Eric E.
分类号 C07H21/02;C07H21/04;C12N15/13;C12N15/113;C12N15/11 主分类号 C07H21/02
代理机构 Hoxie and Associates, LLC 代理人 Hoxie and Associates, LLC
主权项 1. A compound having the formula (XXVI):wherein: T2 is a group comprising a nucleoside, a nucleotide, a monomeric subunit, a reactive ester, a linker, a cleavable moiety or an oligomeric compound.
地址 Carlsbad CA US