发明名称 |
Conjugated antisense compounds and their use |
摘要 |
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. |
申请公布号 |
US9127276(B2) |
申请公布日期 |
2015.09.08 |
申请号 |
US201414267842 |
申请日期 |
2014.05.01 |
申请人 |
Isis Pharmaceuticals, Inc. |
发明人 |
Prakash Thazha P.;Seth Punit P.;Swayze Eric E. |
分类号 |
C07H21/02;C07H21/04;C12N15/13;C12N15/113;C12N15/11 |
主分类号 |
C07H21/02 |
代理机构 |
Hoxie and Associates, LLC |
代理人 |
Hoxie and Associates, LLC |
主权项 |
1. A compound having the formula (XXVI):wherein:
T2 is a group comprising a nucleoside, a nucleotide, a monomeric subunit, a reactive ester, a linker, a cleavable moiety or an oligomeric compound. |
地址 |
Carlsbad CA US |