Real-time self-calibrating sensor system and method

摘要

A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

主权项

1. A system for calibrating a sensor of a characteristic monitoring system in real time by determining, and compensating for, an IR drop across unwanted resistances in a cell, said sensor including a counter electrode, a reference electrode, and a working electrode in communication with a user's blood or interstitial fluids to produce signals indicative of said characteristic, the system comprising:
a first control unit having a potentiostat, said potentiostat including an operational amplifier connected in an electrical circuit to maintain substantial equality between the magnitude of a measured voltage across the sensor's working and reference electrodes and the magnitude of an applied voltage; a current-interrupt switch electrically connected between the operational amplifier's output and the sensor's counter electrode to provide a closed circuit when the switch is closed and an open circuit when the switch is opened; and a second control unit including a microprocessor and connected in the electrical circuit to maintain substantial equality between the magnitude of an optimally desired voltage across the sensor's working and reference electrodes and the magnitude of an effective amount of potential in the cell that drives electrochemical reactions at the working electrode, said effective amount of potential reflecting an adjustment for the magnitude of said IR drop, and said second control unit providing said applied voltage as an input to the operational amplifier,
wherein the second control unit estimates the magnitude of the IR drop through linear regression of acquired open-circuit samples of said measured voltage across the sensor's working and reference electrodes over time and then calculates the magnitude of said effective amount of potential in the cell by subtracting the magnitude of the IR drop from the closed-circuit magnitude of said measured voltage across the sensor's working and reference electrodes; andwherein the magnitude of said effective amount of potential in the cell is optimized by further subtracting therefrom the magnitude of the open-circuit voltage across the sensor's working and reference electrodes.