Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
申请公布号
HK1201557(A1)
申请公布日期
2015.09.04
申请号
HK20150102018
申请日期
2015.02.27
申请人
IMMUNE DESIGN CORP.
发明人
ALLEN, JAMES, M.;VAN HOEVEN, NEAL, S.;LI, JIN ZHONG;SLOAN, DEREK, D.;DUBENSKY, THOMAS W., JR.