摘要 |
<p>The invention discloses the novel pharmacological actions of 5-methoxy flavone hitherto unreported in literature, like sedation, hypnosis, general anesthesia and anticonvulsant effect that will be clinically useful in humans and in veterinary practice. The invention comprises the assay of a formulation of 5-methoxy flavone in 10% Tween-80 or another formulation of. the same in a mix of 20% propylene glycol and 10% Tween-80 administered by intravenous route to induce rapid and short lasting general anesthetic effect in experimental animals like mice and rabbits. The invention also comprises the assay of a formulation of 5-methoxy flavone in 0.5% carboxy methyl cellulose administered intra-peritoneally for establishing the sedative, hypnotic and anticonvulsant action in mice. The above assays reveal that the compound 5-methoxy flavone exhibits a rapid and short acting general anesthetic effect in mice and rabbits after intravenous administration. 5-methoxy flavone also produces sedation, hypnosis and protects against various types of convulsions in mice after intra-peritoneal administration. The assay directed towards determining the acute toxicity of 5-methoxy flavone in mice resulted in establishing the l_D5o (lethal dose in 50% of the population) of the compound as 66mg/kg after intravenous administration and 540mg/kg after intraperitoneal administration.</p> |