CRYSTAL OF DISPIROPYRROLIDINE DERIVATIVE

摘要

The purpose of the present invention is to provide a crystal of a dispiropyrrolindine compound which inhibits Mdm2 activity or a salt thereof. The present invention provides a crystal of (3 R 4 S 5 R) N [(3R 6S) 6 carbamoyltetrahydro 2H pyran 3 yl] 6' chloro 4 (2 chloro 3 fluoropyridine 4 yl) 4 4 dimethyl 2' oxo 1' 2' dihydrodispiro[cyclohexane 1 2 pyrrolidine 3 3' indole] 5 carboxamide which inhibits Mdm2 and exhibits antitumour activity or a salt thereof. The present invention also provides a medicine including these crystals.