A NOVEL LIVE ATTENUATED SHIGELLA VACCINE

摘要

A live attenuated Shigella vaccine, which is based on a rough Shigella strain lacking LPS O -antigen which is non- invasive through a mutation of the invasion plasmid , specifically for use in the immunoprophylaxis of a subject to prevent infectious diseases preferably enteral disease , and a Shigella strain, which is a S. flexneri 2a strain with a deletion of the rfb F, ipa B and/or ipa C genes , as well as a recombinant plasmid vector based on a mutated Shigella invasion plasmid comprising a nucleotide sequence encoding at least one heterologous antigen , wherein the plasmid is mutated in at least one of the ipa B and/or ipa C genes.