发明名称 |
PROCESS FOR PREPARING QUINOLINE DERIVATIVES |
摘要 |
<p>A process for preparing a compound of Formula I is disclosed, comprising the steps: wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl or (C1-C6)alkyl optionally substituted with heterocycloalkyl; R4 is (C1-C6)alkyl; and Q is CH or N; comprising: (a) contacting 1,1-cyclopropane dicarboxylic acid with thionyl chloride in a polar aprotic solvent; (b) adding and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and (c) coupling a compound of Formula A with an amine of Formula B to form a compound of Formula I.</p> |
申请公布号 |
HK1201517(A1) |
申请公布日期 |
2015.09.04 |
申请号 |
HK20150101949 |
申请日期 |
2015.02.26 |
申请人 |
EXELIXIS INC. |
发明人 |
WILSON, JO, ANN;NAGANATHAN, SRIRAM;PFEIFFER, MATTHEW;ANDERSEN, NEIL, G. |
分类号 |
C07C;C07D |
主分类号 |
C07C |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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