ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) DIRECTED TO DOMAIN III AND DOMAIN IV OF HER3

摘要

The present invention relates to antibodies or fragments thereof that bind to a non linear epitope within domain 3 of the HER3 receptor and inhibit both ligand dependent and ligand independent signal transduction. The invention also relates antibodies or fragments thereof that bind to amino acid residues within domains 3 4 of HER3 and inhibit both ligand dependent and ligand independent signal transduction; and compositions and methods of use of such antibodies or fragments thereof.