发明名称 |
ANTIBODIES THAT BIND EGFR AND ERBB3 |
摘要 |
The invention relates in one aspect to bispecific antibodies comprising a first antigen-binding site that binds EGFR and a second antigen-binding site that binds Erb B-3, wherein the antibody has a half maximal growth inhibitory concentration (IC50) of less than 200 p M for inhibiting EGFR and/or Erb B-3 ligand induced growth of Bx PC3 cells or Bx PC3-luc2 cells. Further described are method for producing the bispecific antibodies and means and methods for the treatment of subjects with the antibodies. |
申请公布号 |
CA2941030(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
CA20152941030 |
申请日期 |
2015.02.27 |
申请人 |
MERUS N.V. |
发明人 |
LOGTENBERG, TON;THROSBY, MARK;ROOVERS, ROBERTUS CORNELIS |
分类号 |
C07K16/46;A61K39/395;A61P35/00;A61P35/04;C07K16/28 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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