发明名称 |
PHARMACEUTIC OSMOTIC PUMP PREPARATION |
摘要 |
Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs. |
申请公布号 |
US2015245992(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
US201314436235 |
申请日期 |
2013.10.16 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
Zhang Jiwen;Wu Li;Yin Xianzhen;Guo Zhen;Li Haiyan |
分类号 |
A61K9/00;G01N23/04;A61K31/7052;A61K31/40;A61K47/32;A61K31/192 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Shanghai CN |