发明名称 |
METHOD FOR AIDING DIAGNOSIS OF ALZHEIMER'S DISEASE |
摘要 |
The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprising: (i) determining the number of alleles of ApoE4 in the patient's genome; (ii) determining the combined expression level of at least three platelet proteins in a platelet sample from the patient; and (iii) comparing the resulting value of step (ii) to a control value, wherein the at least three platelet proteins include at least one isoform of alpha-tropomyosin containing exon 1a and at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 or mutant GSTO-1, wherein a result higher than the control value is indicative of Alzheimer's disease.;The invention also provides a solid support comprising one or more ligands of at least one isoform of alpha-tropomyosin containing exon 1a, and one or more ligands of at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 protein and/or mutant GSTO-1 protein immobilised thereon. |
申请公布号 |
US2015247870(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
US201314431557 |
申请日期 |
2013.10.03 |
申请人 |
RANDOX LABORATORIES LTD |
发明人 |
Umlauf Ellen;Zellner Maria |
分类号 |
G01N33/68;G06F19/00;G06F19/18 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
1. An ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprising:
(i) determining the number of alleles of ApoE4 in the patient's genome; (ii) determining the combined expression level of at least three platelet proteins in a platelet sample from the patient; and (iii) comparing the resulting value of step (ii) to a control value, wherein the at least three platelet proteins include at least one isoform of alpha-tropomyosin containing exon 1a and at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 or mutant GSTO-1, wherein a result higher than the control value is indicative of Alzheimer's disease. |
地址 |
Northern Ireland GB |