COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

摘要

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

主权项

1. A compound having the structure of Formula (V): wherein:
R1 is aryl or heteroaryl wherein aryl or heteroaryl is optionally substituted with at least one R3;wherein aryl is selected from phenyl and napthyl,wherein heteroaryl is selected from furan, thiophene, pyrrole, oxazole, thiazole, isothiazole, imidazole, isoxazole, pyrazole, oxadiazole, thiadiazole, benzothiazole, benzoxazole, benzofuran, and indole;R2 is phenyl or pyridyl wherein each is optionally substituted with at least one R4; eachR3 is independently selected from F, Cl, Br, I, CH3, Et, CH2F, CHF2 or CF3;each R4 is independently selected from F, Cl, Br, I, CH3, CH2F, CHF2 or CF3;R5 is H, CH3, Et, isopropyl or allyl; or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.