发明名称 |
TERT-BUTYL N-[2-ETHYL]-L-ALANINATE OR A SALT, HYDRATE OR SOLVATE THEREOF |
摘要 |
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine. |
申请公布号 |
US2015246883(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
US201314436404 |
申请日期 |
2013.10.15 |
申请人 |
CHROMA THERAPEUTICS LTD |
发明人 |
Pintat Stéphane;Davies Stephen John;Moffat David Festus Charles |
分类号 |
C07D213/73 |
主分类号 |
C07D213/73 |
代理机构 |
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代理人 |
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主权项 |
1. A compound which is:
tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate, or a pharmaceutically acceptable salt, hydrate or solvate thereof. |
地址 |
Abingdon, Oxfordshire GB |