发明名称 |
METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH |
摘要 |
The disclosure provides methods of preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and/or reducing the likelihood or severity of heart failure. The disclosure also provides methods of preventing, or treating LV remodeling in a mammalian subject, and/or reducing the likelihood or severity of LV remodeling. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide. In some embodiments, the methods comprise administering to the subject an effective amount of an aromatic cationic peptide to reduce levels of C-reactive protein, tumor necrosis factor alpha, interleukin 6, reactive oxygen species, Nt-pro BNP, and/or cardiac troponin I, and/or reduce expression levels of MLCL AT1 and/or ALCAT 1 in subjects in need thereof. |
申请公布号 |
US2015246092(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
US201314437325 |
申请日期 |
2013.10.22 |
申请人 |
STEALTH PEPTIDES INTERNATIONAL, INC. ;HENRY FORD HEALTH SYSTEMS |
发明人 |
Wilson D. Travis;Sabbah Hani N. |
分类号 |
A61K38/07;A61K45/06;C07K5/11 |
主分类号 |
A61K38/07 |
代理机构 |
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代理人 |
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主权项 |
1. A method for reducing the level of C-reactive protein in a mammalian subject in need thereof, the method comprising: administering to the subject a therapeutically effective amount of the peptide D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof. |
地址 |
Monte-carlo MC |