| 发明名称 |
Piggy Back Delivery of Nucleic Acids Into Organisms |
| 摘要 |
The present invention includes nucleic acid hybrid molecules capable of entering cells comprising at least one vivo-morpholino oligonucleotide (vivo-MO) comprising a guanidine-rich head conjugated to the 5′ end, and at least one standard oligonucleotide comprising a gene-specific sequence and a standard oligonucleotide pairing sequence, wherein the standard oligonucleotide is bound to the vivo-morpholino oligonucleotide through base pairing to form a hybrid and wherein the vivo-morpholino oligonucleotide pairing sequence is complementary to the standard oligonucleotide pairing sequence. |
| 申请公布号 |
US2015247146(A1) |
申请公布日期 |
2015.09.03 |
| 申请号 |
US201514714423 |
申请日期 |
2015.05.18 |
| 申请人 |
University of North Texas |
发明人 |
Jagadeeswaran Pudur |
| 分类号 |
C12N15/113;G01N33/50;A61K48/00;C12Q1/68 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid hybrid molecule capable of entering cells comprising:
at least one vivo-morpholino oligonucleotide (vivo-MO) comprising a guanidine-rich head at the 5′ end; and at least one oligonucleotide comprising a gene-specific sequence and a oligonucleotide pairing sequence, wherein the oligonucleotide is bound to the vivo-morpholino oligonucleotide through base pairing to form a hybrid; andwherein the vivo-morpholino oligonucleotide pairing sequence is complementary to the oligonucleotide pairing sequence. |
| 地址 |
Denton TX US |
