| 摘要 |
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof,;;wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester. |
| 主权项 |
1. A process for preparing a compound of formula (4) or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, comprising treating a compound of formula (6), or salt or a tautomer thereof, wherein R1 is hydrogen or a nitrogen protecting group, with a reducing agent to obtain the compound of formula (4). |
