NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE

摘要

The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

主权项

1. A composition comprising at least two compounds selected from the group consisting of carbetapentane, rilmenidine, acamprosate, baclofen, buphenine, carvedilol, cimetidine, cinacalcet, ciprofibrate, dexbrompheniramine, ifenprodil, metformin, mexiletine, moxonidine, nitrendipine, torasemide and triamterene, or a salt, prodrug, derivative of any chemical purity, or sustained release formulation thereof, for simultaneous, separate or sequential administration.