METHANOL DEHYDROGENASE VARIANT EXHIBITING INCREASED REDUCTION ACTIVITY

摘要

The present invention relates to: a methanol dehydrogenase (MDH) variant which is derived from Bacillus methanolicus and has increased reduction activity; a polynucleotide encoding the enzyme; an expression vector comprising the polynucleotide; a transformant into which the expression vector is introduced; a method for preparing the MDH variant by culturing the transformant; a method for producing methanol from formaldehyde by using the MDH variant; and a use of the MDH variant for producing methanol from formaldehyde. The production yield of methanol can be increased by using the MDH variant of the present invention since the reduction activity is improved to be more than that of a conventional MDH, and thus the MDH variant could be widely applied to a more effective preparation of methanol.