发明名称 |
DPI formulation containing sulfoalkyl ether cyclodextrin |
摘要 |
<p>An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.</p> |
申请公布号 |
AU2013201437(B2) |
申请公布日期 |
2015.09.03 |
申请号 |
AU20130201437 |
申请日期 |
2013.03.12 |
申请人 |
CYDEX PHARMACEUTICALS, INC |
发明人 |
PIPKIN, JAMES D.;ZIMMERER, RUPERT O.;HICKEY, ANTHONY J.;THOMPSON, DIANE O.;SMYTH, HUGH D. C. |
分类号 |
A61K9/00;A61K9/12;A61K9/14;A61K47/40;C08B37/16 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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