COMPOSITIONS, METHODS AND USES FOR POXVIRUS ELEMENTS IN VACCINE CONSTRUCTS AGAINST INFLUENZA VIRUS SUBTYPES OR STRAINS

摘要

Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.

主权项

1. A construct comprising:
a modified vaccinia virus construct having at least one poxvirus secretory signal sequence associated with a first influenza gene segment or fragment thereof, andat least a second influenza gene segment or fragment thereof,wherein the influenza gene segments in the construct are capable of producing an immune response to more than one influenza subtype when introduced to a subject.