Stable Quick Dissolving Dosage Form Comprising Amoxicillin and Clavulanic Acid

摘要

A quick dissolving pharmaceutical formulation is disclosed. In one embodiment, the formulation includes at least the following components: (1) from about 35 to about 50 weight percent amoxicillin or a pharmaceutically acceptable salt thereof; (2) from about 2.0 to about 12 weight percent clavulanic acid or a pharmaceutically acceptable salt thereof; (3) from about 30 to about 40 weight percent mannitol; (4) from about 2 to about 7 weight percent crospovidone; (5) from about 0.5 to about 2.0 weight percent colloidal silicon dioxide; and (6) from about 2.0 to about 5.0 weight percent sodium stearyl fumarate. A method for making a quick dissolving pharmaceutical tablet is also disclosed.

主权项

1. A quick dissolving pharmaceutical formulation comprising:
from about 35 to about 50 weight percent of a first active ingredient which comprises amoxicillin or a pharmaceutically acceptable salt thereof; from about 2.0 to about 12 weight percent of a second active ingredient which comprises clavulanic acid or a pharmaceutically acceptable salt thereof; from about 30 to about 40 weight percent mannitol; from about 2 to about 7 weight percent crospovidone; from about 0.5 to about 2.0 weight percent colloidal silicon dioxide; and from about 2.0 to about 5.0 weight percent sodium stearyl fumarate.