PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS

摘要

The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels:;;The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

主权项

1. A compound of formula I or I′ or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: G is X is a bond or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; RX is absent, H, or C3-C8 cycloaliphatic, wherein up to two non-adjacent CH2 units of said C3-C8 cycloaliphatic may be replaced with —O— and said C3-C8 cycloaliphatic is substituted with 0-3 substituents selected from halogen and C1-C4 alkyl; R1 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen and wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; R2 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; R3 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; R4 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; R5 is H, halogen, CN, or —X—RX; R5′ is H, halogen, CN, or —X—RX; R6 is H, halogen, CN, or —X—RX; R6′ is H, halogen, CN, or —X—RX; R7 is H, halogen, CN, or —X—RX; R8 is halogen, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—; p is an integer from 0 to 3 inclusive; and R9 is H, or C1-C6 alkyl wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—.