TRAINING METHODS FOR IMPROVED ASSAYING OF PAIN IN CLINICAL TRIAL SUBJECTS

摘要

Provided are methods for training subjects to report pain, and for identifying accurate pain reporting subjects prior to or subsequent to training. The methods of the invention generally involve: determining the reported pain threshold and tolerance levels of the subject in response to an evoked pain stimulus; determining the reported pain of the subject in response to a natural index pain using a standard pain reporting scale; determining the response profile of the subject to noxious stimuli using a standard pain reporting scale, wherein the noxious stimuli intensity are between the pain threshold and tolerance levels of the subject; and determining the pain reporting accuracy and/or reliability of the subject.

主权项

1. A method of training a subject to report pain comprising:
a) determining the reported pain threshold and tolerance levels of the subject in response to an evoked pain stimulus; b) determining the reported pain of the subject in response to a natural index pain using a standard pain reporting scale; c) determining the response profile of the subject to noxious stimuli using a standard pain reporting scale, wherein the noxious stimuli intensity are between the pain threshold and tolerance levels of the subject; d) determining the pain reporting accuracy and/or reliability of the subject by analysis of the data collected in (a), (b), and (c); e) providing instructional feedback to the subject regarding the accuracy and reliability of their pain reporting; and f) repeating steps (a) to (e) one or more times.