EFFICIENT ENCODING AND STORAGE AND RETRIEVAL OF GENOMIC DATA

摘要

A new method for encoding genomic data that reduces storage footprint by two orders of magnitude while preserving acceptable quality data.

主权项

1. A method for compressing genomic data, the method comprising the steps of:
(i) providing a computer having a memory in functional communication with a processor; (ii) inputting multiple segments of genomic sequences and their quality scores into the computer memory; (iii) providing reference genomic data comprising a sequence of genomic data; (iv) accessing the reference genomic data; (v) aligning the multiple segments with the reference genomic data; (vi) comparing individual nucleotides in the aligned multiple segments using the processor; (vii) creating a de-duplicated sequence of encoded data aligned with the reference genomic data; wherein the encoded data contains nucleotide labels for agreed upon nucleotides at a particular nucleotide location.