SCAFFOLD FOR CARDIAC PATCH

摘要

A biocompatible and biodegradable medical device patch actuating primarily as soft tissue structural reinforcement. The device has a layered architecture, where the primary serves as suturing layer and mechanical support to a thick porous scaffold which can be coated with a mimic-like extra cellular matrix (ECM). The device can be provided to the end user under the format of independent layers that can be cut and assembled to the specific need to the end user and patient. The layers are assembled without the need of any adhesive. Totally haemocompatible and of behavior superior to polytetrafluoroethylene used for any soft tissue repaired, the field of this invention is demonstrated for cardiovascular therapy but should not be limited to it. It is of practical relevance of vein, tendon and hernias and dermal treatments.

主权项

1. A composition comprising:
a) a biocompatible and biodegradable scaffold comprising synthetic and natural polymers, wherein the synthetic polymer is selected from polylactic acid, glycolic acid, lactone, polyglicerol sebacate, copolymer of synthetic polymers and combinations thereof, and wherein the natural polymer is selected from chitosan, sodium alginate and cellulose; b) a hydrogel comprising self assembling peptides, wherein the self assembling peptides are selected form the sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and combinations thereof; and c) a support comprising polyurethane.