METHODS AND COMPOSITIONS FOR PROGNOSTIC RISK ANALYSIS OF CLEAR CELL RENAL CELL CARCINOMA

摘要

Provided are methods for distinguishing clear cell type A (ccA) renal cell carcinoma from clear cell type B (ccB) renal cell carcinoma in a subject. In some embodiments, the method include the steps of obtaining a biological sample from a subject that has clear cell renal cell carcinoma (ccRCC); assaying the biological sample to determine an expression level for one or more and optionally all thirty-four of the gene products listed in Table 1 in the biological sample; and comparing the expression level(s) determined to a statistically validated reference. Also provided are methods for generating prognostic signatures for subject with ccRCC, methods for assessing risk of an adverse outcome of a subject with ccRCC, methods for predicting a clinical outcome of a treatment in a subject having ccRCC, and arrays that can be employed in the practice of the presently disclosed methods.